A Guide to Office Space in St. Louis

Finding office space for rent in St. Louis is a smart business move. The thriving local economy is diverse, the location is strategic, and the quality of life is rich but affordable.

The “Gateway to the West” is a city with a strong sense of community. There are high-quality universities, colleges, and professional sports teams. St. Louis has terrific art and history museums too, and a world-class symphony orchestra.

The city’s economy is growing in the healthcare, tech, and manufacturing industries. Businesses can also benefit from many support and growth programs here. Finding skilled team members is easy too, with an immense talent pool at Washington University and Saint Louis University.

St. Louis is an excellent place for business, which is why there are plentiful office space opportunities. In this article, we’ll share why the city is so great, along with nine attractive options for St. Louis office space.

Geography of St. Louis

St. Louis, Missouri, is a thriving metropolis in the heart of the Midwest. The St. Louis region includes four counties: Franklin County, Jefferson County, St. Charles County, and St. Louis County, plus the city of St. Louis.

Situated where the Missouri and Mississippi rivers meet, St. Louis has long been a key player in transportation and logistics. Its port and rail network make it a major center for moving goods around the US and beyond.

St. Louis’ strategic location has made it a hub for innovation and economic growth. The city has a robust healthcare and biomedical sector, with almost 40% of residents having a college degree. The area’s cost of living is 6.9% below the national average too.

The region’s location, economy, and business infrastructure make it a compelling choice. Businesses can position themselves for success in this dynamic market by renting office space in St. Louis.

Key business areas in St. Louis

Finding big or small office space for rent in St. Louis is easy. From the bustling streets of Downtown to the innovation hubs of the Central West End, here’s a look at some key areas to consider.

• Downtown St. Louis: This is the historic heart of the city. It’s home to many corporate headquarters and financial institutions. The well-connected area has easy access to highways, rail, and the riverfront.
• Central West End: This area attracts startups, tech companies, and creative professionals. The area offers a mix of office spaces and amenities that cater to a diverse business community.
• Creve Coeur: The home of the bioscience and healthcare industries. Medical research facilities and pharmaceutical companies appreciate this educated workforce and convenient location.
• Clayton: This area is St. Louis County’s business and government center. Law firms, financial service companies, and corporate headquarters choose it for easy access.
• Chesterfield: This suburban setting is ideal for those seeking offices outside the city center. Companies choose this area for its highway access and proximity to residential areas.
• The Cortex Innovation Community: This growing innovation hub has impressive facilities and strong transport links. Plus, venture capital opportunities are plentiful here.
• Sunset Hills: With a growing number of business parks and diverse companies, this is an attractive location for businesses. It strikes a good balance between urban and suburban environments.

5 businesses based in St. Louis

When you move into an office for rent in St. Louis, your business will be in good company. Your neighbors could include some of the area’s most prominent organizations:

• BJC HealthCare: This is one of the top nonprofit healthcare organizations in the country, employing over 29,000 people in the St. Louis area.
• Washington University: A major employer and a beacon of higher education.
• Mercy Hospital: This company’s extensive healthcare system includes hospitals and clinics. Each provides vital services across the region.
• Boeing Defense, Space & Security: This business is a critical player in aerospace. Its presence in St. Louis reinforces the city’s reputation as a hub for innovation and technology.
• SSM Health: A nonprofit Catholic health system. It manages a range of healthcare facilities and services.

Why you should rent office space in St. Louis, MO

St. Louis offers several key advantages that make it an attractive destination for a wide range of companies of all sizes.

1. Diversified economy

St. Louis has a robust and diverse economy. Industries such as healthcare, financial services, manufacturing, and technology are driving its growth. The city is home to many Fortune 500 companies too.

The region enjoys the advantages of a diversified economy and stability. This has led to a thriving startup and innovation ecosystem. Such diversity is also essential for economic growth and resilience.

2. Supportive small business environment

St. Louis has become a vibrant hub for small businesses and entrepreneurs. The city offers a range of resources to support new ventures. This includes startup incubators and business plan competitions that provide funding and mentorship.

The low cost of living and affordable office space for rent in St. Louis makes it an attractive location for all kinds of businesses.

3. Affordability

St. Louis is becoming a hotspot for tech professionals and companies. Unlike expensive tech hubs like Silicon Valley, St. Louis’ affordability makes it ideal. It’s also ranked as one of the top 10 most cost-effective cities for businesses.

4. Railroad hub

St. Louis stands out as the third-largest rail hub in the nation. It has six Class I railroads, each moving goods all over the country. The city’s strategic location and rail infrastructure enhance its logistical capabilities. For workers here, the city has a great public transport network too.

5. Access to resources

Businesses in St. Louis have access to a wealth of resources to support growth. Tax credits, grants, and loan programs through initiatives like the Missouri Works program exist.

Organizations like the St. Louis Economic Development Partnership offer capital, mentorship, and resources. The talent pool is rich too, with a steady stream of skilled graduates from local universities.

6. St. Louis culture

St. Louis has plentiful culture, cuisine, and entertainment offerings. The city’s culinary landscape surprises many. You’ll want to sample regional dishes and specialties such as toasted ravioli and St. Louis-style pizza.

The arts scene in St. Louis is undeniably vibrant. There’s always something to do, from prestigious museums and orchestras to live music. Plus, St. Louis is the home of the Gateway Arch, Lemp Mansion, and Delmar Loop.

How much are St. Louis office space rentals?

Office space for rent in St. Louis is an affordable option. Compared to major tech hubs across the US, rent here is well below the national average.

Here, the average cost is $23.19 per square foot each year. In Seattle, the same space starts at $94 per square foot. In Austin, that number is $84.21. Office space in Downtown St. Louis and the surrounding area is far less expensive than other comparable cities.

Office space for rent in St. Louis

Our office space for rent in St. Louis provides everything the modern business needs, no matter what industry you’re in. Choose one of these options for St. Louis office space.

Deloitte Building

The Deloitte Building is a notable landmark in St. Louis’ business district. Its distinct curved front makes it an impressive place for any business to call home.

Inside, the large windows offer inspiring views of the Gateway Arch. While outside, you’re a short walk from the Missouri River and places to unwind.

This space offers a central location and stunning views. With plenty of breakout areas, it’s also ideal for networking. The Deloitte Building is an attractive spot for businesses looking for office space for rent in Downtown St. Louis.

Highlights include

• Parking
• Meeting rooms
• On-site lunch restaurant

Information about the Deloitte Building

• Location: 100 South 4th Street, St. Louis, MO 63102
• Starting cost: From $225 per month
• Opening hours: 24-hour access for Private Office and Dedicated Desk members, 8:30 am to 5:30 pm weekday access for other members
• Nearby transport links: 7th St & Market St N/E Bus Stop (a seven-minute walk away)

4625 Lindell Boulevard

Lindell Boulevard has a workspace that fits how you want to work. The space is ideal for sparking new ideas and embracing collaboration.

This affordable and creative office space in St. Louis puts you in the middle of a tech-savvy community. It’s also close to universities, shops, and restaurants. This office is close to Forest Park too, which makes for a great lunchtime walk.

There are private offices, coworking spots, and virtual offices here. All options have fast internet, meeting spaces, and many other business services.

Highlights include

• Break-out areas
• Meeting rooms
• Parking

Information about 4625 Lindell Boulevard

• Location: 4625 Lindell Boulevard, St. Louis, MO 63108
• Starting cost: From $255 per month
• Opening hours: 24-hour access for Private Office and Dedicated Desk members, 8:30 am to 5:30 pm weekday access for other members
• Nearby transport links: Lindell & Euclid EB Bus Stop (a four-minute walk away)

100 Chesterfield Business Parkway

100 Chesterfield Business Parkway offers an excellent business location in the city’s “Bio Belt.” Known for its concentration of biotech and science companies, other businesses invested in this sector would do well here.

The building is modern, with a striking red and cream brick exterior. Inside, businesses enjoy high-quality finishes and amenities. At a minimum, this ensures you offer a great first impression for your visitors and staff. There’s an on-site coffee bar to keep productivity high all day too.

This location offers coworking and private office space in St. Louis that meets the needs of any team. Plus, it’s close to a variety of great dining options for after-work networking or unwinding.

Highlights include

• Break-out areas
• Disabled facilities
• Business lounge

Information about 100 Chesterfield Business Parkway

• Location: 100 Chesterfield Business Parkway, St. Louis, MO 63005
• Starting cost: From $275 per month
• Opening hours: 24-hour access for Private Office and Dedicated Desk members, 8:30 am to 5:30 pm weekday access for other members
• Nearby transport links: Chesterfield Airport @ Long EB Bus stop (a five-minute walk away)

2055 Craigshire Rd

2055 Craigshire Rd is the perfect spot to energize your business. This beautiful building features floor-to-ceiling windows and an impressive atrium lobby. The location offers convenient access to I-270 and Highway 364, as well as the St. Louis Lambert International Airport.

Businesses enjoy amenities including a private parking lot, breakout areas, and a stocked kitchen. With plenty of natural light here, there’s inspiration at every turn. Choose from open-plan offices, coworking spaces, and meeting rooms here.

This office’s convenient location makes it ideal for businesses seeking both large and small office space for rent in St. Louis.

Highlights include

• Meetings rooms
• Private parking lot
• Fully stocked kitchens

Information about 2055 Craigshire Rd

• Location: 2055 Craigshire Rd., St. Louis, MO 63146
• Starting cost: Prices available upon request
• Opening hours: 24-hour access for Private Office and Dedicated Desk members, 8:30 am to 5:30 pm weekday access for other members
• Nearby transport links: Craig @ Lackland SB Bus Stop (an 11-minute walk away)

12645 Olive Blvd

12645 Olive Blvd is an exciting workspace designed to support productivity. This space offers beautiful workspaces with everything you need to grow your business in St. Louis.

Whether you need coworking or private office space in St. Louis, this location caters to both. There are also customizable long-term spaces. Plus, you can use this address to set up a virtual office if you’re not ready to move yet.

The Creve Coeur area has a vibrant small business community and is just off I-270. There are plenty of nearby dining and entertainment options.

Highlights include

• Break-out areas
• Meeting rooms
• City/town center location

Information about 12645 Olive Blvd

• Location: 12645 Olive Blvd., Creve Coeur, MO, 63141
• Starting cost: Prices available upon request
• Opening hours: 24-hour access for Private Office and Dedicated Desk members, 8:30 am to 5:30 pm weekday access for other members
• Nearby transport links: Olive @ Barnes West EB Bus Stop (a six-minute walk away)

Ellisville Pointe

Ellisville Pointe is your gateway to business elevation. This St. Louis office space puts you among several high-growth industries, including aerospace and publishing.

Convenience is unmatched with this location, with easy transport links and plenty of amenities nearby. Local and international travel is a breeze too, with St. Louis Lambert International Airport close by.

This office space is in a bustling commercial and retail zone. You’ll find many options for leisure and relaxation, from parks to bowling.

Highlights include

• Break-out areas
• Meeting rooms
• Fully stocked kitchens

Information about Ellisville Pointe

• Location: 15620 Manchester Road, Ellisville, MO 63011
• Starting cost: Prices available upon request
• Opening hours: 24-hour access for Private Office and Dedicated Desk members, 8:30 am to 5:30 pm weekday access for other members
• Nearby transport links: Manchester @ Meadow EB Bus Stop (a two-minute walk away)

111 Westport Plaza Drive

Grow your business at 111 Westport Plaza Drive. This location places you at a central point with excellent connections to the city.

The “Gold Tower” stands out with its shared areas and well-equipped meeting rooms, all boasting stunning views. The surrounding bars and restaurants offer plenty of options for socializing after work too.

Amenities at this location include conference rooms, an on-site receptionist, and IT support. Its proximity to key spots in St. Louis makes it convenient for businesses looking for growth and accessibility.

Highlights include

• Business lounge
• Airport location
• Gym and fitness room

Information about 111 Westport Plaza Drive

• Location: 111 Westport Plaza, St. Louis, MO 63146
• Starting cost: From $239 per month
• Opening hours: 24-hour access for Private Office and Dedicated Desk members, 8:30 am to 5:30 pm weekday access for other members
• Nearby transport links: Westport Plaza @ Progress Parkway EB Bus Stop (a three-minute walk away)

Two CityPlace Drive

At Two CityPlace Drive, discover an office space that elevates your workday experience. This location features a stunning curved building with views of the surrounding lake.

For those seeking improved productivity, the breakout areas and natural light provide all you need. The space is also a natural hub for networking, with several other businesses already thriving here.

Amenities include a cafe, furnished and equipped meeting rooms, and on-site support staff. Located in busy Creve Coeur, there’s easy access to hotels, dining, and shopping.

Highlights include

• Gym and fitness room
• On-site lunch restaurant
• Outside seating area/terrace

Information about Two CityPlace Drive

• Location: Two CityPlace Drive, 2nd Floor, Creve Coeur, MO, 63141
• Starting cost: From $305 per month
• Opening hours: 24-hour access for Private Office and Dedicated Desk members, 8:30 am to 5:30 pm weekday access for other members
• Nearby transport links: New Ballas @ City Place SB Bus Stop (a two-minute walk away)

Explore St. Louis office spaces with Regus

When renting St. Louis office space from Regus, you become part of an affordable and growing business community.

We offer a full range of office solutions to meet the diverse needs of businesses in St. Louis, with plenty of options to scale up or down. With access to furnished offices, high-speed internet, and on-site support, businesses can focus on growth with us.

Contact one of our specialists to learn more about how Regus can meet your business needs for office space in St. Louis.